Sodium Hydroxide → HCID 87549243, compound

HRID 508115Notes

Reaction equation

HRID 508115 reaction equation
[C:1]([NH:4][C:5]1[C:10]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]([O:18][CH2:19][C:20]3([OH:28])[CH2:25][CH2:24][S:23](=[O:27])(=[O:26])[CH2:22][CH2:21]3)=[CH:13][C:12]=2[CH3:29])=[CH:9][C:8]([CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][C:40]([OH:42])=[O:41])=[C:34]([F:43])[CH:33]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[OH-].[Na+].[Cl-].[Ca+2:47].[Cl-]>CO>[Ca+2:47].[C:1]([NH:4][C:5]1[C:10]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]([O:18][CH2:19][C:20]3([OH:28])[CH2:21][CH2:22][S:23](=[O:27])(=[O:26])[CH2:24][CH2:25]3)=[CH:13][C:12]=2[CH3:29])=[CH:9][C:8]([CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][C:40]([O-:42])=[O:41])=[C:34]([F:43])[CH:33]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:1]([NH:4][C:5]1[C:10]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]([O:18][CH2:19][C:20]3([OH:28])[CH2:21][CH2:22][S:23](=[O:27])(=[O:26])[CH2:24][CH2:25]3)=[CH:13][C:12]=2[CH3:29])=[CH:9][C:8]([CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][C:40]([O-:42])=[O:41])=[C:34]([F:43])[CH:33]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5284359Calcium ChlorideHCID 59434134HCID 59434134, compound

Product 1

HCID 87549243HCID 87549243, compoundYield 44.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-{4-[({6-(acetylamino)-4′-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2′,6′-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoic acid (86.3 mg, 0.14 mmol) in methanol (1 mL) was added 1 M sodium hydroxide solution (0.14 mL). Successively, an aqueous solution of calcium chloride (8.7 mg, 0.07 mmol) was gradually added. The precipitated solid was collected by filtration, washed with water, and vacuum dried to give the title compound (39.2 mg, yield 44%) as a colorless amorphous powder.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water, and vacuum
  3. customdried

Sources & evidence

ORD record
ord-7c041d2fbc3f496eb536bcd08d83ecd0
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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