4-Hydroxybenzaldehyde → 4-(3,3,3-Trifluoro-2-hydroxypropoxy)benzaldehyde

HRID 508152Notes

Reaction equation

HRID 508152 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.Br[CH2:11][CH:12]([OH:17])[C:13]([F:16])([F:15])[F:14]>>[F:14][C:13]([F:16])([F:15])[CH:12]([OH:17])[CH2:11][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1264-HydroxybenzaldehydeHCID 2206323-Bromo-1,1,1-Trifluoro-2-Propanol

Product 1

HCID 582842464-(3,3,3-Trifluoro-2-hydroxypropoxy)benzaldehydeYield 84%

Procedure

The title compound is prepared analogously to Example 12A from 4-hydroxybenzaldehyde and 3-bromo-1,1,1-trifluoropropan-2-ol.

Sources & evidence

ORD record
ord-46ed9a3c18e14c6d91bcfe5547d2bd2b
Source dataset
uspto-grants-2015_08
Patent number
US09095582B2

Reaction notes

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