Sodium Hydroxide → HCID 68279051, compound

HRID 508203Notes

Reaction equation

HRID 508203 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[C:3]=1[C:4]([N:6]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[C:8]([C:16]2[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[C:18]([OH:25])[CH:17]=2)=[N:7]1)=[O:5].[OH-].[Na+:35]>O>[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:31])([F:33])[F:32])[C:3]=1[C:4]([N:6]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[C:8]([C:16]2[CH:24]=[CH:23][C:19]([C:20]([O-:22])=[O:21])=[C:18]([OH:25])[CH:17]=2)=[N:7]1)=[O:5].[Na+:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68278907HCID 68278907, compound

Product 1

HCID 68279051HCID 68279051, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of compound 26A (48 mg, 0.1 mmol) in H2O (20 mL) was added 0.1 M NaOH (1 mL), and the mixture was sonicated for ˜10 mins. The mixture was then dried under lyophilizaiton to give the title compound. LCMS (ESI) calc'd for C22H11ClF4N2NaO4 [M+H]+: 501. found: 501; 1H NMR (400 MHz, MeOD) δ 8.45 (1H, d, J=8.0), 7.91-7.76 (5H, m), 7.31 (1H, q, J=8.0 Hz), 7.20-7.17 (2H, m).

Workup

  1. customthe mixture was sonicated for ˜10 mins
  2. customThe mixture was then dried under lyophilizaiton

Sources & evidence

ORD record
ord-fd6b3257ebb74e9a8a378bf830f4309e
Source dataset
uspto-grants-2015_08
Patent number
US09095583B2

Reaction notes

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