Acetone → HCID 86722321, compound

Temperature

25 °C

10 g of 2-butanoyloxy-5-nitro-benzoic acid, 8.5 ml of dioxane, 1.5 ml of HCl 4M solution in dioxane and 1.0 g of Pd/C at 5% were loaded into a 300 ml reactor at 16±2° C. After two vacuum-nitrogen cycles, the reactor was saturated with hydrogen at 10 bar and kept at 16±2° C. for 6 hours. At the end, nitrogen atmosphere was restored in the reactor and the reaction mixture was added with 125 ml of acetone at 25° C. The suspension was stirred at 25° C. for 30 minutes to obtain the dissolution of the undissolved product and the carbon suspension was filtered on a celite panel which was then washed with 60 ml of acetone. The resultant solution was then evaporated under vacuum at 30° C. and the solid residue was dried under vacuum at 35° C. for 4 hours to obtain 10 g of the expected product (99% yield).

1. customto obtain
2. dissolutionthe dissolution of the undissolved product
3. filtrationthe carbon suspension was filtered on a celite panel which
4. washwas then washed with 60 ml of acetone
5. customThe resultant solution was then evaporated under vacuum at 30° C.
6. customthe solid residue was dried under vacuum at 35° C. for 4 hours

ORD record

ord-3f81788c2a514014a98fb86c266bedcb

Source dataset

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09096491B2