反应详情

温度

90 °C

To a solution of 4-iodophenol (75 mg, 0.34 mmol) in a mixture of water (1 mL) and 1,4-dioxane (2 mL) was added [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid (Preparation 7, 90 mg, 0.46 mmol), dichlorobis(triphenylphosphine)palladium(II) (18.3 mg, 0.03 mmol) and cesium carbonate (240 mg, 0.74 mmol). The resulting mixture was heated at 90° C. in a Reactivial™ for 4 hours. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate (10 mL) and brine (2×10 mL). The organic extract was dried over anhydrous sodium sulfate and evaporated in vacuo. The crude material was purified by flash column chromatography using the ISCO™ system (12 g column), eluting with 70:30 heptane/ethyl acetate. Fractions containing product were combined and concentrated in vacuo to afford the title compound as a white solid (61 mg, 73%).

1. temperatureThe reaction mixture was cooled to room temperature
2. custompartitioned between ethyl acetate (10 mL) and brine (2×10 mL)
3. extractionThe organic extract
4. dry with materialwas dried over anhydrous sodium sulfate
5. customevaporated in vacuo
6. customThe crude material was purified by flash column chromatography
7. washeluting with 70:30 heptane/ethyl acetate
8. additionFractions containing product
9. concentrationconcentrated in vacuo