Hydrazine hydrate (1:1) → 3-methyl-1H-pyrazole-4-carbohydrazide
Reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]([O:9]CC)=O.O.[NH2:13][NH2:14]>C(O)C>[CH3:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]([NH:13][NH2:14])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
In a 25 mL sealed tube, ethyl 5-methyl-1H-pyrazole-4-carboxylate (0.25 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Hydrazine hydrate (1 mL, 5 eq.) was introduced dropwise at RT and the reaction mixture was heated at 120° C. for 20 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude 5-methyl-1H-pyrazole-4-carbohydrazide (0.24 g) which was used without further purification in the following step.
Workup
- customIn a 25 mL sealed tube
- concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)
Sources & evidence
- ORD record
- ord-5f5ee538b225470d9944e8aada0b3ebf
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09096543B2
Reaction notes
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