Hydrazine hydrate (1:1) → (3-Methoxy-4-nitrophenyl)hydrazine

HRID 508770ノート

反応式

HRID 508770 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.O.[NH2:14][NH2:15]>C(O)C>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([NH:14][NH2:15])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 27792505-Fluoro-2-nitroanisole

生成物 1

HCID 21883922(3-Methoxy-4-nitrophenyl)hydrazine収率 74.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4-fluoro-2-methoxy-1-nitrobenzene (2.5 g, 14.60 mmol) in ethanol (25 mL) was added hydrazine hydrate (2.1 g, 43.8 mmol). The reaction mixture was refluxed for 3-4 h. The reaction mixture was concentrated to afford 2.0 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 3.84 (s, 3H), 4.46 (s, 2H), 6.31 (d, J=9.3 Hz, 1H), 6.50 (s, 1H), 7.83 (d, J=9.3 Hz, 1H), 8.25 (s, 1H); MS (m/z): (184.01 M)+.

後処理

  1. temperatureThe reaction mixture was refluxed for 3-4 h
  2. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-a72d234a2f9546a0b1264446188d39bf
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

反応ノート

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