Hydrochloric Acid → 5-(Aminomethyl)-2-chlorobenzoic acid hydrochloride

HRID 508817Notes

Reaction equation

HRID 508817 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12]C(=O)C(F)(F)F)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>CO>[ClH:1].[NH2:12][CH2:11][C:8]1[CH:9]=[CH:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 584832772-Chloro-5-[(trifluoroacetamido)methyl]benzoic acid

Product 1

HCID 671163655-(Aminomethyl)-2-chlorobenzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Workup

  1. temperatureThe reaction mixture was refluxed for 18 h
  2. concentrationThe reaction mixture was concentrated
  3. customcrude reaction mixture

Sources & evidence

ORD record
ord-ad64199f0c824d0b97a8ab35a29dc303
Source dataset
uspto-grants-2015_08
Patent number
US09096545B2

Reaction notes

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