Oxalyl chloride → 3-Fluoro-4-iodobenzoyl isocyanate

HRID 508898Notes

Reaction equation

HRID 508898 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([NH2:7])=[O:6].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([N:7]=[C:13]=[O:14])=[O:6]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 535838293-Fluoro-4-iodobenzamide

Product 1

HCID 900191213-Fluoro-4-iodobenzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 3-fluoro-4-iodobenzamide (2.0 g), oxalyl chloride (0.120 mL) and EDC (25 mL) to afford 1.0 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-494a9dc3530b49688d48cf5fce3ab2ad
Source dataset
uspto-grants-2015_08
Patent number
US09096545B2

Reaction notes

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