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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 509072Generated: October 29, 2026

Water → HCID 136492433, compound

https://huagongshe.com/reaction/509072

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantLithium HydroxideHCID 3939—
ReactantHCID 136247008HCID 136247008—
SolventTetrahydrofuranHCID 8028—
ProductHCID 136492433HCID 13649243363.2%

Reaction Steps

The title compound was prepared by following the procedure as described in step-2 of Intermediate-106 by using N-(4-chloro-3-(3-(4-(cyclopropylethynyl)phenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)benzyl)-2,2,2-trifluoroacetamide (Example-190, 0.100 g), LiOH (0.100 g), water (2.0 mL), THF (10.0 mL) to afford 0.050 g of the desired product. MS (m/z): 365.83 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096545B2
Source datasetuspto-grants-2015_08
ORD IDord-d0a8962c7bbc435d9f55c0ff2f1bd77a
Source noteuspto-grants-2015_08