HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 136492433, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 136247008 | HCID 136247008 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 136492433 | HCID 136492433 | 63.2% |
Reaction Steps
The title compound was prepared by following the procedure as described in step-2 of Intermediate-106 by using N-(4-chloro-3-(3-(4-(cyclopropylethynyl)phenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)benzyl)-2,2,2-trifluoroacetamide (Example-190, 0.100 g), LiOH (0.100 g), water (2.0 mL), THF (10.0 mL) to afford 0.050 g of the desired product. MS (m/z): 365.83 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096545B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d0a8962c7bbc435d9f55c0ff2f1bd77a |
| Source note | uspto-grants-2015_08 |