Water → HCID 136492433, compound

HRID 509072Notes

Reaction equation

HRID 509072 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7]C(=O)C(F)(F)F)=[CH:4][C:3]=1[N:16]1[C:20](=[O:21])[NH:19][C:18]([C:22]2[CH:27]=[CH:26][C:25]([C:28]#[C:29][CH:30]3[CH2:32][CH2:31]3)=[CH:24][CH:23]=2)=[N:17]1.[Li+].[OH-].O>C1COCC1>[NH2:7][CH2:6][C:5]1[CH:14]=[CH:15][C:2]([Cl:1])=[C:3]([N:16]2[C:20](=[O:21])[NH:19][C:18]([C:22]3[CH:27]=[CH:26][C:25]([C:28]#[C:29][CH:30]4[CH2:32][CH2:31]4)=[CH:24][CH:23]=3)=[N:17]2)[CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 136247008HCID 136247008, compound

Product 1

HCID 136492433HCID 136492433, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by following the procedure as described in step-2 of Intermediate-106 by using N-(4-chloro-3-(3-(4-(cyclopropylethynyl)phenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)benzyl)-2,2,2-trifluoroacetamide (Example-190, 0.100 g), LiOH (0.100 g), water (2.0 mL), THF (10.0 mL) to afford 0.050 g of the desired product. MS (m/z): 365.83 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d0a8962c7bbc435d9f55c0ff2f1bd77a
Source dataset
uspto-grants-2015_08
Patent number
US09096545B2

Reaction notes

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