Ammonia → HCID 54591671, compound

HRID 509257Notes

Reaction equation

HRID 509257 reaction equation
[NH3:1].[CH:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH:3]1[NH:12][C:13]([C:15]1[N:20]=[C:19]([N:21]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29](OC)=[O:30])[CH2:23][CH2:22]3)[CH:18]=[CH:17][CH:16]=1)=[O:14])[CH2:9]2>CO>[CH:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH:3]1[NH:12][C:13](=[O:14])[C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([N:21]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29]([NH2:1])=[O:30])[CH2:23][CH2:22]3)[N:20]=1)[CH2:9]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54591669HCID 54591669, compound

Product 1

HCID 54591671HCID 54591671, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

7N ammonia in methanol (2 ml) was added into methyl 3-(4-(6-(adamantan-2-ylcarbamoyl)pyridin-2-yl)piperazin-1-yl)propanoate (94 mg, 0.22 mmol), and then the resulting mixture was stirred at room temperature for 48 hours. The resulting reaction liquid was concentrated under reduced pressure, and then the residue thus obtained was subjected to MPLC (10% MeOH/MC), to obtain 54 mg of colorless oil (60%). MS (ESI): 412 [M+H]

Workup

  1. customThe resulting reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customthe residue thus obtained

Sources & evidence

ORD record
ord-bd5cd926bc344149bb0859c93851f639
Source dataset
uspto-grants-2015_08
Patent number
US09096571B2

Reaction notes

Loading…