反应详情

4-bromobenzenesulfonyl chloride (200 mg, 0.783 mmol) was dissolved in MC (10 ml), followed by dropwise addition of tert-butylamine (0.41 ml, 3.91 mmol) at 0° C., and then the resulting mixture was stirred at room temperature under nitrogen stream for 1 hour. Distilled water (15 ml) was added to the resulting reaction liquid, followed by extraction with MC (30 ml×2). The organic layer was dried over anhydrous sodium sulfate, followed by filtration and concentration, and then the residue thus obtained was dried under vacuum, to obtain 228 mg of white solid (100%).

1. extractionfollowed by extraction with MC (30 ml×2)
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. filtrationfollowed by filtration and concentration
4. customthe residue thus obtained
5. customwas dried under vacuum