Hydrochloric Acid → HCID 71144421, compound

HRID 509323Notes

Reaction equation

HRID 509323 reaction equation
CC([S@@]([NH:7][C@H:8]([C:19]1[C:24]([CH3:25])=[CH:23][CH:22]=[CH:21][N:20]=1)[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)=O)(C)C.[ClH:26].O1CCOCC1>CO>[ClH:26].[CH3:25][C:24]1[C:19]([C@H:8]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:11][CH:10]=2)[NH2:7])=[N:20][CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71144442HCID 71144442, compound

Product 1

HCID 71144421HCID 71144421, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (S)-2-methyl-N—((S)-(3-methylpyridin-2-yl)(4-(trifluoro-methyl)phenyl)methyl)propane-2-sulfinamide (0.355 g, 0.958 mmol) in MeOH (10 mL) was treated with hydrogen chloride, 4.0 M solution in 1,4-dioxane (0.6 mL, 2.400 mmol) and stirred at rt. The reaction was concentrated on the rotary evaporator resulting in a gummy residue. The residue (S)-(3-methylpyridin-2-yl)-(4-(trifluoromethyl)phenyl)methanamine hydrochloride was used in the next steps without further purification.

Workup

  1. concentrationThe reaction was concentrated on the rotary evaporator
  2. customresulting in a gummy residue
  3. customThe residue (S)-(3-methylpyridin-2-yl)-(4-(trifluoromethyl)phenyl)methanamine hydrochloride was used in the next steps without further purification

Sources & evidence

ORD record
ord-e184224e6a1e421e93f8462a07448bc9
Source dataset
uspto-grants-2015_08
Patent number
US09096527B2

Reaction notes

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