HCID 178418361, compound → HCID 178423880, compound

HRID 509621Notes

Reaction equation

HRID 509621 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9](/[CH:11]=[CH:12]/[C:13]3[NH:14][CH:15]=[C:16]([C:18]4[O:19][C:20]([CH3:23])=[CH:21][CH:22]=4)[N:17]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][CH2:12][C:13]3[NH:14][CH:15]=[C:16]([C:18]4[O:19][C:20]([CH3:23])=[CH:21][CH:22]=4)[N:17]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178423879HCID 178423879, compound

Product 1

HCID 178423880HCID 178423880, compoundYield 30%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 5-Methyl-2-{(E)-2-[4-(5-methyl-furan-2-yl)-1H-imidazol-2-yl]-vinyl}-[1,2,4]triazolo[1,5-a]pyridine (20 mg, 0.07 mmol) in methanol (20 mL) was added 10% palladium on carbon (20 mg). The reaction was shaken under 3 bar atmosphere of hydrogen overnight. Filtration and evaporation of the volatiles afforded the title compound (6 mg, 30%). LC-MS: m/z=308.3 (MH+), tR=0.41 minutes, method A.

Workup

  1. filtrationFiltration and evaporation of the volatiles

Sources & evidence

ORD record
ord-b8d4af0057d44057b4283904cee09b6f
Source dataset
uspto-grants-2015_08
Patent number
US09096589B2

Reaction notes

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