Trifluoroacetic acid → HCID 178426228, compound

HRID 509624Notes

Reaction equation

HRID 509624 reaction equation
[CH3:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][C:13]3[N:14](COCC[Si](C)(C)C)[CH:15]=[C:16]([C:18]4[S:19][CH:20]=[CH:21][CH:22]=4)[N:17]=3)[N:10]=[C:6]2[N:5]=[C:4]([CH3:31])[CH:3]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>C(Cl)Cl>[OH:36][C:34]([C:33]([F:38])([F:37])[F:32])=[O:35].[CH3:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][C:13]3[NH:14][CH:15]=[C:16]([C:18]4[S:19][CH:20]=[CH:21][CH:22]=4)[N:17]=3)[N:10]=[C:6]2[N:5]=[C:4]([CH3:31])[CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53251470HCID 53251470, compound

Product 1

HCID 178426228HCID 178426228, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine (360 mg, 0.79 mmol) in DCM (4.5 mL) was added trifluoroacetic acid (4.5 mL). The reaction was shaken under an atmosphere of argon for 16 hours. The volatiles were removed in vacuo to yield the title compound as the TFA salt. LC-MS: m/z=324.5 (MH+), tR=0.33 minutes, method A.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-35bb6ae4dadd4d98b99b1559cec9ee9f
Source dataset
uspto-grants-2015_08
Patent number
US09096589B2

Reaction notes

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