2-Methyl-5-vinylpyridine → HCID 57876097, compound

HRID 509736Notes

Reaction equation

HRID 509736 reaction equation
[F:1][CH:2]([F:23])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:22][CH2:21][C:12]3[NH:13][C:14]4[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][C:19]=4[C:11]=3[CH2:10]2)=[CH:5][CH:4]=1.[CH3:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]=[CH2:32])=[CH:27][N:26]=1.[OH-].[K+]>CN1C(=O)CCC1>[F:23][CH:2]([F:1])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:22][CH2:21][C:12]3[N:13]([CH2:32][CH2:31][C:28]4[CH:27]=[N:26][C:25]([CH3:24])=[CH:30][CH:29]=4)[C:14]4[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][C:19]=4[C:11]=3[CH2:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 88172-Methyl-5-vinylpyridineHCID 14797Potassium HydroxideHCID 68760131HCID 68760131, compound

Product 1

HCID 57876097HCID 57876097, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from a mixture of 2-(4-(difluoromethyl)phenyl)-2,3,4,5-tetrahydro-8-methyl-1H-pyrido[4,3-b]indole, 2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Workup

  1. customranging between 25 deg C
  2. customto 100 deg C
  3. customThe product obtained
  4. customis isolated by preparative HPLC

Sources & evidence

ORD record
ord-91f3313ebae045d79868a91f49845ca0
Source dataset
uspto-grants-2015_08
Patent number
US09096591B2

Reaction notes

Loading…