Trifluoroacetic acid → HCID 117856453, compound

HRID 509903Notes

Reaction equation

HRID 509903 reaction equation
[Cl-:1].C(OC([NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][N+:12]([CH2:31][CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([O:40][CH2:41][C:42]([O:44][CH3:45])=[O:43])=[CH:36][CH:35]=2)([CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:21][CH:20]=2)[CH2:11]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[ClH:1].[Cl-:1].[NH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][N+:12]([CH2:31][CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([O:40][CH2:41][C:42]([O:44][CH3:45])=[O:43])=[CH:36][CH:35]=2)([CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:23][CH:24]=2)[CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117856345HCID 117856345, compound

Product 1

HCID 117856453HCID 117856453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-tert-Butoxycarbonylamino-1,1-bis-[3-(4-methoxycarbonylmethoxy-phenyl)-propyl]-piperidinium chloride (707 mg, 1.09 mmol) is dissolved in dichloromethane (1 ml) and trifluoroacetic acid (1 ml) and stirred at room temperature overnight. The mixture is evaporated, dissolved in acetonitrile and 1 M HCl (5 ml) and evaporated again. LC (method L): tR=0.95 min; Mass spectrum (ESI+): m/z=513 [M]+.

Workup

  1. customThe mixture is evaporated
  2. dissolutiondissolved in acetonitrile
  3. custom1 M HCl (5 ml) and evaporated again

Sources & evidence

ORD record
ord-b568d82401dd4ea9ad9ae02b82c72da8
Source dataset
uspto-grants-2015_08
Patent number
US09096548B2

Reaction notes

Loading…