HCID 57963062, compound → HCID 67200711, compound

HRID 509972Notes

Reaction equation

HRID 509972 reaction equation
C1(S([N:10]2[C:14]3=[N:15][CH:16]=[C:17]([O:19][CH3:20])[CH:18]=[C:13]3[C:12](I)=[CH:11]2)(=O)=O)C=CC=CC=1.C(OC(=O)[N:28]([CH2:37][C:38]1[C:39]([O:45][CH3:46])=[N:40][CH:41]=[C:42]([F:44])[CH:43]=1)[C:29]1[N:34]=[CH:33][C:32]([CH:35]=O)=[CH:31][N:30]=1)(C)(C)C>>[F:44][C:42]1[CH:43]=[C:38]([CH2:37][NH:28][C:29]2[N:30]=[CH:31][C:32]([CH2:35][C:12]3[C:13]4[C:14](=[N:15][CH:16]=[C:17]([O:19][CH3:20])[CH:18]=4)[NH:10][CH:11]=3)=[CH:33][N:34]=2)[C:39]([O:45][CH3:46])=[N:40][CH:41]=1

Participants

3

Reactant 2

HCID 57963062HCID 57963062, compoundHCID 591287071-(Benzenesulfonyl)-3-iodo-5-methoxy-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 67200711HCID 67200711, compound

Procedure

(5-Fluoro-2-methoxy-pyridin-3-ylmethyl)-[5-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyrimidin-2-yl]-amine P-1599 is prepared in three steps from 1-benzenesulfonyl-3-iodo-5-methoxy-1H-pyrrolo[2,3-b]pyridine 16 and (5-fluoro-2-methoxy-pyridin-3-ylmethyl)-(5-formyl-pyrimidin-2-yl)-carbamic acid tert-butyl ester 123 as shown in Scheme 13.

Sources & evidence

ORD record
ord-f9be122e05434f3381e54f545d409aae
Source dataset
uspto-grants-2015_08
Patent number
US09096593B2

Reaction notes

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