Ammonia → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide

HRID 510031Notes

Reaction equation

HRID 510031 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11](OCC)=[O:12])=[N:9][N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:5]2=[N:6][CH:7]=1.[NH3:24]>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:10]([C:11]([NH2:24])=[O:12])=[N:9][N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 56849011ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxylate

Product 1

HCID 568490095-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.00 g (3.152 mmol) of the compound obtained in example 25A was stirred in 10 ml of a 7N solution of ammonia in methanol at RT for three days. This was followed by concentration under reduced pressure. This gave 908 mg (99% of theory) of the title compound.

Workup

  1. concentrationThis was followed by concentration under reduced pressure

Sources & evidence

ORD record
ord-5a40b655cb8d4055b61f2577971a6eea
Source dataset
uspto-grants-2015_08
Patent number
US09096592B2

Reaction notes

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