HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxylate | HCID 56849011 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide | HCID 56849009 | — |
Reaction Steps
1.00 g (3.152 mmol) of the compound obtained in example 25A was stirred in 10 ml of a 7N solution of ammonia in methanol at RT for three days. This was followed by concentration under reduced pressure. This gave 908 mg (99% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096592B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5a40b655cb8d4055b61f2577971a6eea |
| Source note | uspto-grants-2015_08 |