反应详情

192 mg (approx. 0.517 mmol) of the compound from example 38A were dissolved in dimethylformamide (4 ml), then 34.5 mg (0.862 mmol) of sodium hydride (60% in mineral oil) were added and the mixture was stirred at RT for 30 min. Then 129 mg (0.744 mmol) of 6-chloro-3-nitropyridin-2-amine were added and the reaction mixture was stirred at RT for 1 h. The mixture was added to water, and the solids were filtered off, washed repeatedly with water and dried under high vacuum overnight. This gave 348 mg (85% purity, 84% of theory) of the title compound in solid form.

1. stirringthe reaction mixture was stirred at RT for 1 h
2. filtrationthe solids were filtered off
3. washwashed repeatedly with water
4. customdried under high vacuum overnight