反应详情

温度

100 °C

500 mg (0.980 mmol) of the compound from example 82A were dissolved in 10 ml of DMF, 414 mg (1.270 mmol) of cesium carbonate and 150 mg (1.08 mmol) of 2-(bromomethyl)oxetane were added and the mixture was stirred at RT for 18 h, at 40° C. for 18 h and at 100° C. for 4 h. After cooling, water was added and the mixture was extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated on a rotary evaporator. The residue was dried under high vacuum. 581 mg (53% of theory, purity 63%) of the title compound were obtained.

1. temperatureAfter cooling
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. concentrationconcentrated on a rotary evaporator
5. customThe residue was dried under high vacuum