HRID510067

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13725757

未命名化合物

结构：COc1ccc(Cn2c(=O)[nH]c3cnc(-c4nn(Cc5ccccc5F)c5ncc(F)cc45)nc32)c(OC)c1

HCID66614016

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cn2c(=O)n(CCS(C)(=O)=O)c3cnc(-c4nn(Cc5ccccc5F)c5ncc(F)cc45)nc32)c(OC)c1

HCID66614300

未命名化合物

PROCEDURE

实验过程

300 mg (0.567 mmol) of the compound from example 93A were reacted in analogy to the method in example 83A with 2-bromoethyl methyl sulfone. 490 mg (100% of theory, 73% purity) of the title compound were obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-86c72874a33e49dbac243f64c5e91045
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09096592B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH3:1][O:2][C:3]1[CH:37]=[C:36]([O:38][CH3:39])[CH:35]=[CH:34][C:4]=1[CH2:5][N:6]1[C:14](=[O:15])[NH:13][C:12]2[C:7]1=[N:8][C:9]([C:16]1[C:24]3[C:19](=[N:20][CH:21]=[C:22]([F:25])[CH:23]=3)[N:18]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[F:33])[N:17]=1)=[N:10][CH:11]=2.[CH3:40][S:41]([CH2:44][CH2:45]Br)(=[O:43])=[O:42]>>[CH3:1][O:2][C:3]1[CH:37]=[C:36]([O:38][CH3:39])[CH:35]=[CH:34][C:4]=1[CH2:5][N:6]1[C:14](=[O:15])[N:13]([CH2:45][CH2:44][S:41]([CH3:40])(=[O:43])=[O:42])[C:12]2[C:7]1=[N:8][C:9]([C:16]1[C:24]3[C:19](=[N:20][CH:21]=[C:22]([F:25])[CH:23]=3)[N:18]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[F:33])[N:17]=1)=[N:10][CH:11]=2