1-Bromo-2-(methylsulfonyl)ethane → 9-(2,4-Dimethoxybenzyl)-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-[2-(methylsulfonyl)ethyl]-7,9-dihydro-8H-purin-8-one

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-2-(methylsulfonyl)ethane	HCID 13725757	—
Reactant	9-(2,4-Dimethoxybenzyl)-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one	HCID 66614016	—
Product	9-(2,4-Dimethoxybenzyl)-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-[2-(methylsulfonyl)ethyl]-7,9-dihydro-8H-purin-8-one	HCID 66614300	—

Reaction Steps

300 mg (0.567 mmol) of the compound from example 93A were reacted in analogy to the method in example 83A with 2-bromoethyl methyl sulfone. 490 mg (100% of theory, 73% purity) of the title compound were obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096592B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-86c72874a33e49dbac243f64c5e91045
Source note	uspto-grants-2015_08