2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-methyl-7,9-dihydro-8H-purin-8-one → 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-methyl-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

Under an argon atmosphere, 225 mg (approx. 0.112 mmol) of the compound from example 107 were dissolved in 15 ml of dimethylformamide, admixed with 150 mg of 10% palladium on charcoal and hydrogenated under standard hydrogen pressure overnight. The reaction mixture was filtered through Celite and concentrated, and the residue was purified by means of preparative HPLC (eluent: water/acetonitrile/water with 1% trifluoroacetic acid, gradient 60:35:5→35:60:5). 33 mg of the title compound were obtained (76% of theory).

Provenance & Evidence