反应详情

Under an argon atmosphere, 225 mg (approx. 0.112 mmol) of the compound from example 107 were dissolved in 15 ml of dimethylformamide, admixed with 150 mg of 10% palladium on charcoal and hydrogenated under standard hydrogen pressure overnight. The reaction mixture was filtered through Celite and concentrated, and the residue was purified by means of preparative HPLC (eluent: water/acetonitrile/water with 1% trifluoroacetic acid, gradient 60:35:5→35:60:5). 33 mg of the title compound were obtained (76% of theory).

1. custompressure overnight
2. filtrationThe reaction mixture was filtered through Celite
3. concentrationconcentrated
4. customthe residue was purified by means of preparative HPLC (eluent: water/acetonitrile/water with 1% trifluoroacetic acid, gradient 60:35:5→35:60:5)