反应详情

80 mg (0.22 mmol) of the compound from example 68 were initially charged in methanol (4 ml), then 12 mg (0.045 mmol) of platinum(IV) oxide were added and the reaction mixture was hydrogenated at standard pressure overnight. The reaction mixture was filtered through Celite and the filtercake was washed with methanol. The filtrate was concentrated to give 79 mg (92% purity, 90% of theory) of the title compound, which were converted without further purification.

1. customwas hydrogenated at standard pressure overnight
2. filtrationThe reaction mixture was filtered through Celite
3. washthe filtercake was washed with methanol
4. concentrationThe filtrate was concentrated