反应详情

Isopropylamine (4.5 ml) and N,N-diisopropylethylamine (13.2 ml) were dissolved into 150 ml dichloromethane. The mixture was added dropwise to a solution of 2,4-dichloro-5-nitro-6-methylpyrimidine (10.7 g) in dichloromethane (30 ml) at 0° C. After the completion of the dropwise addition, the mixture was kept at the same temperature to react for half an hour. Purification was conducted by a column chromatography to obtain a bright-yellow solid (10.2 g) in a yield of 86.8%. 1H NMR (400 MHz, CDCl3): δ 8.01 (s, 1H), 4.48 (m, J=4.1, 1H), 2.72 (s, 3H), 1.32 (d, J=6.8 Hz, 6H) ppm.

1. additionAfter the completion of the dropwise addition
2. customto react for half an hour
3. customPurification