反应详情

To the product of Example 112, step f (356 mg, 0.91 mmol) in EtOH (9 mL) was added a catalytic amount of 10% Pd/C Degussa type followed by a balloon of hydrogen gas. The mixture was stirred at room temperature overnight. The balloon was refilled with hydrogen gas and an additional spatula tip of 10% Pd/C was added. After an additional 24 h and the reaction was complete. The catalyst was removed by filtration and the liquid was concentrated in vacuo to afford the desired product (268 mg, 98%). MS (ESI) mass calcd. C16H21N5O, 299.2. m/z found 300.2 [M+H]+.

1. waitAfter an additional 24 h
2. customThe catalyst was removed by filtration
3. concentrationthe liquid was concentrated in vacuo