Sodium Hydroxide → HCID 178481727, compound

HRID 510323Notes

Reaction equation

HRID 510323 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[N:13]=[CH:12]3)[N:4]=1.[OH-].[Na+]>Cl>[CH3:18][N:14]1[C:15]2[C:11](=[CH:10][C:9]([C:5]3[N:4]=[C:3]([OH:2])[CH:8]=[CH:7][N:6]=3)=[CH:17][CH:16]=2)[CH:12]=[N:13]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866998545-(4-methoxypyrimidin-2-yl)-1-methyl-1H-indazole

Product 1

HCID 178481727HCID 178481727, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
85 °C

Procedure

5-(4-methoxypyrimidin-2-yl)-1-methyl-1H-indazole (30.2 mg, 0.126 mmol) was suspended in hydrochloric acid (1.25 mL of a 2N solution) and heated at 85° C. for 14 h, cooled, and neutralized by dropwise addition of NaOH (2N solution). The mixture was extracted six times with 1:1 chloroform/isopropanol and the combined organic layers were dried over Na2SO4 and concentrated to provide the crude product which was used without further purification. LCMS-ESI+: calc'd for C12H11N4O: 227.1 (M+H+); Found: 227.2 (M+H+).

Workup

  1. temperaturecooled
  2. extractionThe mixture was extracted six times with 1:1 chloroform/isopropanol
  3. dry with materialthe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-58b7208e9dcd4dd0b414a143cbd9e61e
Source dataset
uspto-grants-2015_08
Patent number
US09096586B2

Reaction notes

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