反应详情

温度

85 °C

5-(4-methoxypyrimidin-2-yl)-1-methyl-1H-indazole (30.2 mg, 0.126 mmol) was suspended in hydrochloric acid (1.25 mL of a 2N solution) and heated at 85° C. for 14 h, cooled, and neutralized by dropwise addition of NaOH (2N solution). The mixture was extracted six times with 1:1 chloroform/isopropanol and the combined organic layers were dried over Na2SO4 and concentrated to provide the crude product which was used without further purification. LCMS-ESI+: calc'd for C12H11N4O: 227.1 (M+H+); Found: 227.2 (M+H+).

1. temperaturecooled
2. extractionThe mixture was extracted six times with 1:1 chloroform/isopropanol
3. dry with materialthe combined organic layers were dried over Na2SO4
4. concentrationconcentrated