反应详情

温度

85 °C

A mixture of methyl 2-cyano-3-[2-methyl-3-(trifluoromethyl)phenyl]propanoate (2.2 g, 8.1 mmol) and hydrazine monohydrate (4.1 g, 81 mmol) in ethanol (150 mL) was heated to 85° C. overnight. Reaction mixture was concentrated to dryness. The residue was redissolved with DCM (200 mL) and water (30 mL). Two layers were separated. Organic layers were dried and concentrated to dryness. Desired product was obtained and used in next step. (2.11 g, 96%); LC/MS: MS (ES+) m/e 272 (MH+).

1. customReaction mixture
2. concentrationwas concentrated to dryness
3. dissolutionThe residue was redissolved with DCM (200 mL) and water (30 mL)
4. customTwo layers were separated
5. customOrganic layers were dried
6. concentrationconcentrated to dryness