反应详情

温度

100 °C

To a solution of ethyl 3-(2-chlorophenyl)-2-cyanopropanoate (2.37 g, 10 mmol) in ethanol (20 mL) and acetic acid (20 mL) under nitrogen was added hydrazine monohydrate (2.5 g, 49.9 mmol). The reaction mixture was heated and stirred at 100° C. overnight. Reaction mixture was concentrated. Oily residue was dissolved with ethyl acetate (60 mL) and 5% HCl solution (15 mL). Two layers were separated. Organic layer was washed with brine (15 mL), dried and concentrated to give product. It was used in next step without purification. (1.98 g, 89%); LC/MS: MS (ES+) m/e 224 (MH+)

1. temperatureThe reaction mixture was heated
2. customReaction mixture
3. concentrationwas concentrated
4. dissolutionOily residue was dissolved with ethyl acetate (60 mL) and 5% HCl solution (15 mL)
5. customTwo layers were separated
6. washOrganic layer was washed with brine (15 mL)
7. customdried
8. concentrationconcentrated
9. customto give product
10. customIt was used in next step without purification