Sodium Methoxide → 5-Methoxypyrazin-2-amine

Temperatur

150 °C

To a solution of 5-chloropyrazin-2-amine (0.2 g, 1.54 mmol) in MeOH (3 mL) was added Cu powder (0.13 g, 2.07 mmol), followed by a solution of sodium methoxide in MeOH (0.38 mL, 1.75 mmol). The reaction mixture was stirred at 150° C. in a sealed tube for 24 h. The reaction mixture was then filtered through Celite, and the filtrate was concentrated in vacuo. The crude product obtained was purified by column chromatography (silica: 100-200 mesh, MeOH:DCM 2-3%) to afford the title compound (0.13 g, 67%). LCMS (ES+) 126 (M+H)+, RT 1.06 minutes (method 1).

1. filtrationThe reaction mixture was then filtered through Celite
2. concentrationthe filtrate was concentrated in vacuo
3. customThe crude product obtained
4. customwas purified by column chromatography (silica: 100-200 mesh, MeOH:DCM 2-3%)

ORD-Eintrag

ord-c152f26eb31a4bbea52973eb03b99b8e

Quelldatensatz

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09096614B2