Hydrogen Bromide → [7-(2-Amino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester

HRID 510561ノート

反応式

HRID 510561 の反応式
[CH2:1]([O:3][C:4](=[O:37])[NH:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([CH2:16][CH2:17][NH:18]C(OCC3C=CC=CC=3)=O)=[CH:11][CH:12]=2)[CH:7]1[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[CH:31]=1)[CH3:2].Br>C(O)(=O)C.C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:37])[NH:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([CH2:16][CH2:17][NH2:18])=[CH:11][CH:12]=2)[CH:7]1[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[CH:31]=1)[CH3:2]

参加物

5

反応物 2

HCID 260Hydrogen BromideHCID 57476722[7-(2-Benzyloxycarbonylamino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester

生成物 1

HCID 57467359[7-(2-Amino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester収率 105.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

To [7-(2-benzyloxycarbonylamino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-carbamic acid ethyl ester (500 mg, 0.960 mmol) was added at room temperature 8 ml of 33% HBr in acetic acid. After 2 h the mixture was diluted with CH2Cl2, washed twice with NaHCO3, dried and filtered. The solvent was evaporated to obtain the product as a yellow oil (392 mg), which was used without further purification.

後処理

  1. washwashed twice with NaHCO3
  2. customdried
  3. filtrationfiltered
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-ddef695df4864fabb8aeea2c7844d32e
出典データセット
uspto-grants-2015_08
特許番号
US09096619B2

反応ノート

読み込み中…