2-Fluoro-4-(trifluoromethyl)benzaldehyde → 2-Methoxy-4-(trifluoromethyl)benzaldehyde

HRID 510586Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 510586
F[C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][O-:15].[Na+]>>[CH3:14][O:15][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Komponenten

3

Edukt 2

HCID 5229292-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 10942334Sodium Methoxide

Produkt 1

HCID 49847042-Methoxy-4-(trifluoromethyl)benzaldehydeAusbeute 85 %

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2-Fluoro-4-(trifluoromethyl)benzaldehyde (5.0 g, 26 mmol) was diluted with sodium methoxide (57 ml of 0.5 M in methanol; 29 mmol), heated to 50° C. and stirred for 6 hours. The reaction was then partially concentrated, diluted with ethyl acetate and water. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield 2-methoxy-4-(trifluoromethyl)benzaldehyde (4.5 g, 22 mmol, 85% yield).

Aufarbeitung

  1. concentrationThe reaction was then partially concentrated
  2. additiondiluted with ethyl acetate and water
  3. customThe layers were separated
  4. dry with materialthe organic layer was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6e93e24f57ed4f2eaee1874c26441e06
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096567B2

Notizen zur Reaktion

Wird geladen…