反应详情

温度

160 °C

Methyl 6-bromo-7-fluoro-3,4-dihydro-2H-chromene-4-carboxylate (415 mg, 1.44 mmol) was diluted with N-methylpyrrolidone (5 mL) followed by the addition of Cu(I)CN (643 mg, 7.18 mmol). The reaction was bubbled with argon for 20 minutes, then heated at 160° C. under a slight argon bubble for 6 hours. The reaction was cooled to ambient temperature and loaded directly onto a Biotage 25 column eluting with 5% ethyl acetate/hexanes to 100% ethyl acetate to yield the title compound (260 mg, 77.0% yield).

1. customThe reaction was bubbled with argon for 20 minutes
2. custombubble for 6 hours
3. temperatureThe reaction was cooled to ambient temperature
4. washeluting with 5% ethyl acetate/hexanes to 100% ethyl acetate