Methyl iodide → 7-(3-(2-Chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

HRID 51082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 51082
[Cl:1][C:2]1[CH:27]=[C:26]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH:25]=[CH:24][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][CH:15]([C:19]([O:21]CC)=[O:20])[O:16]2)=[CH:11][CH:10]=1.I[CH3:35]>>[Cl:1][C:2]1[CH:27]=[C:26]([O:28][CH2:29][C:30]([F:31])([F:33])[F:32])[CH:25]=[CH:24][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][C:15]([CH3:35])([C:19]([OH:21])=[O:20])[O:16]2)=[CH:11][CH:10]=1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 22737360Ethyl 7-(3-(2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)-chromane-2-carboxylate

Produkt 1

HCID 101403337-(3-(2-Chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

Versuchsvorschrift

The title compound was prepared from ethyl 7-(3-(2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)-chromane-2-carboxylate (Example 5, Step D) following the procedure described in Example 1, Step C employing iodomethane instead of iodoethane followed by hydrolysis as described in Example 5, Step E.

Aufarbeitung

  1. customfollowed by hydrolysis

Quellen und Nachweise

ORD-Eintrag
ord-c892b6ffb31a4379bd07c1ee78c692ef
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713508B2

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