反应详情

温度

80 °C

To a solution of sodium hydrogenecarbonate (0.21 g, 2.5 mmol) in water (5 mL) was added a solution of 6-acetyl-2-bromo-4-chloro-3-methylphenyl trifluoromethanesulfonate (0.50 g, 1.3 mmol) in toluene (5 mL) followed by (3-fluorophenyl)boronic acid (0.21 g, 1.5 mmol) and tetrakis(triphenylphosphine)palladium(0) (75 mg, 0.065 mmol). The mixture was bubbled with N2 for 5 min and then heated at 80° C. overnight. The reaction was diluted with water and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, concentrated and purified on silica gel (eluting with 0-20% of ethyl acetate in hexanes) to give the desired product (0.40 g, 93%). LCMS calculated for C15H12BrClFO (M+H)+: m/z=341.0. found: 341.0.

1. customThe mixture was bubbled with N2 for 5 min
2. additionThe reaction was diluted with water
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. concentrationconcentrated
6. custompurified on silica gel (eluting with 0-20% of ethyl acetate in hexanes)