反应详情

A mixture of tert-butyl 3-[3-chloro-5-(1-chloroethyl)-2-fluoro-6-methoxyphenyl]azetidine-1-carboxylate (0.070 g, 0.18 mmol) and sodium azide (0.036 g, 0.56 mmol) in DMF (0.66 mL) was stirred at room temperature overnight. After diluting with ether, the mixture was washed with water, dried over MgSO4 and concentrated to give the crude azide which was used in the next step without further purification. LCMS calculated for C17H22ClFN4O3Na (M+Na)+: m/z=407.1. found: 407.0.

1. washthe mixture was washed with water
2. dry with materialdried over MgSO4
3. concentrationconcentrated