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HRID510995

反应详情

EQUATION

反应方程式

HRID 510995 反应方程式

REACTANTS

反应物

1
Tert-butyl (1-{4-cyano-2-ethoxy-5-methyl-3-[5-(methylsulfonyl)pyridin-3-yl]phenyl}ethyl)carbamate 分子结构式
HCID86666909

Tert-butyl (1-{4-cyano-2-ethoxy-5-methyl-3-[5-(methylsulfonyl)pyridin-3-yl]phenyl}ethyl)carbamate

C23H29N3O5S

PRODUCTS

产物

1
HCID 86666910 分子结构式
HCID86666910

未命名化合物

收率 149.8%

AUXILIARIES

试剂、催化剂与溶剂

2
Hydrochloric Acid 分子结构式
溶剂HCID313

Hydrochloric Acid

ClH

1,4-Dioxane 分子结构式
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The tert-butyl (1-{4-cyano-2-ethoxy-5-methyl-3-[5-(methylsulfonyl)pyridin-3-yl]phenyl}ethyl)carbamate (0.030 gm, 0.065 mmol) was dissolved in 4.0 M HCl in dioxane (2 mL) and was stirred for 1 hour. The reaction was concentrated in vacuo to give 4-(1-aminoethyl)-3-ethoxy-6-methyl-2-[5-(methylsulfonyl)pyridin-3-yl]benzonitrile as a semi-solid (0.035 g, 100%). LCMS calculated for C18H22N3O3S (M+H)+: m/z=360.1. found: 360.2.

WORKUP

后处理

  1. concentrationThe reaction was concentrated in vacuo