反应详情

温度

60 °C

Acetyl chloride (3.6 mL, 51 mmol) was added to 4-chloro-3-fluorophenol (5.1 g, 35 mmol) and the resulting mixture was heated at 60° C. for 2 hours. Aluminum trichloride (7.0 g, 52 mmol) was added and the mixture was heated at 180° C. for 30 minutes. The mixture was cooled to room temperature. The mixture was cooled to 0° C. and 1 N HCl solution (100 mL) was added dropwise over 30 minutes. The precipitate was washed well with water and dried under vacuum to give the desired compound (6.6 g, 100%).

1. temperaturethe mixture was heated at 180° C. for 30 minutes
2. temperatureThe mixture was cooled to room temperature
3. temperatureThe mixture was cooled to 0° C.
4. washThe precipitate was washed well with water
5. customdried under vacuum