m-Chloroperbenzoic acid → HCID 86666927, compound

HRID 511010Notes

Reaction equation

HRID 511010 reaction equation
[Cl:1][C:2]1[C:3]([CH3:30])=[C:4]([CH:28]=[CH2:29])[C:5]([O:26][CH3:27])=[C:6]([CH:8]([NH:10][C:11]2[N:19]=[CH:18][N:17]=[C:16]3[C:12]=2[N:13]=[CH:14][N:15]3[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][O:21]2)[CH3:9])[CH:7]=1.ClC1C=CC=C(C(OO)=[O:39])C=1>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:30])=[C:4]([CH:28]2[CH2:29][O:39]2)[C:5]([O:26][CH3:27])=[C:6]([CH:8]([NH:10][C:11]2[N:19]=[CH:18][N:17]=[C:16]3[C:12]=2[N:13]=[CH:14][N:15]3[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][O:21]2)[CH3:9])[CH:7]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 86666928HCID 86666928, compound

Product 1

HCID 86666927HCID 86666927, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-[1-(5-chloro-2-methoxy-4-methyl-3-vinylphenyl)ethyl]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (740 mg, 1.7 mmol) was stirred in methylene chloride (5.7 mL) and m-chloroperbenzoic acid (2.1 g, 8.7 mmol) was added. The mixture was stirred overnight. The suspension was filtered and the solids were washed with dichloromethane. Evaporation of the filtrates gave the desired compound.

Workup

  1. filtrationThe suspension was filtered
  2. washthe solids were washed with dichloromethane
  3. customEvaporation of the filtrates

Sources & evidence

ORD record
ord-92a403cf441f43178f3361bbe50cd754
Source dataset
uspto-grants-2015_08
Patent number
US09096600B2

Reaction notes

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