7-(4-hydroxybut-1-ynyl)-9,9-dimethyl-9H-fluoren-2-ol → 7-(4-Hydroxybutyl)-9,9-dimethyl-9H-fluoren-2-ol

HRID 511064Notes

Reaction equation

HRID 511064 reaction equation
[OH:1][CH2:2][CH2:3][C:4]#[C:5][C:6]1[CH:18]=[C:17]2[C:9]([C:10]3[CH:11]=[CH:12][C:13]([OH:21])=[CH:14][C:15]=3[C:16]2([CH3:20])[CH3:19])=[CH:8][CH:7]=1>C1COCC1>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:18]=[C:17]2[C:9]([C:10]3[CH:11]=[CH:12][C:13]([OH:21])=[CH:14][C:15]=3[C:16]2([CH3:19])[CH3:20])=[CH:8][CH:7]=1

Participants

3

Reactant 1

HCID 667982407-(4-hydroxybut-1-ynyl)-9,9-dimethyl-9H-fluoren-2-ol

Product 1

HCID 667982457-(4-Hydroxybutyl)-9,9-dimethyl-9H-fluoren-2-ol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-(4-Hydroxybut-1-ynyl)-9,9-dimethyl-9H-fluoren-2-ol is hydrogenated to completion in THF on palladium/active carbon. The catalyst is filtered off, the solvent is removed in vacuo, and the residue is employed in the next step without further purification.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed in vacuo
  3. customthe residue is employed in the next step without further purification

Sources & evidence

ORD record
ord-01e10d96016d4d9d90c765d070546e78
Source dataset
uspto-grants-2015_08
Patent number
US09096795B2

Reaction notes

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