反应详情

(R)-3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester (559 mg; 3.0 mmol), 4-fluoro-1-nitro-2-trifluoromethyl-benzene (627 mg; 3.0 mmol), potassium carbonate (1.24 g; 9.0 mmol), potassium iodide (498 mg; 3.0 mmol), acetonitrile (6 mL) and water (2 mL) are mixed together and the resulting reaction mixture heated to efflux for 5 hours. The phases are separated and the organic phase dried (MgSO4) and concentrated under high vacuum. The residue is then triturated with diethyl ether, dried under high vacuum to afford the desired compound (1.12 g; 2.98 mmol).

1. customthe resulting reaction mixture
2. temperatureheated to efflux for 5 hours
3. customThe phases are separated
4. dry with materialthe organic phase dried (MgSO4)
5. concentrationconcentrated under high vacuum
6. customThe residue is then triturated with diethyl ether
7. customdried under high vacuum