反应详情

A mixture of 1-(4-tert-butyl-phenyl)-piperazine (1.09 mg; 5.0 mmol), 4-bromo-butyric acid ethyl ester (975 mg; 5.0 mmol), potassium carbonate (691 mg; 5.0 mmol) and potassium iodide (914 mg; 5.5 mmol) in acetonitrile (15 mL) is heated to reflux for 2 hours. The reaction mixture is allowed to attain room temperature and all solids removed by filtration. The filtration residue is washed with acetonitrile and the filtrate concentrated under high vacuum to afford the desired compound (1.41 g; 4.24 mmol).

1. temperatureis heated
2. temperatureto reflux for 2 hours
3. customto attain room temperature
4. customall solids removed by filtration
5. washThe filtration residue is washed with acetonitrile
6. concentrationthe filtrate concentrated under high vacuum