HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Bromo-2-methylisoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Methyl 3-bromo-2-(bromomethyl)benzoate | HCID 21907554 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-2-methylisoindolin-1-one | HCID 21907534 | — |
Reaction Steps
A solution of methylamine in ethanol (10 mL, 80 mmol, 8M solution in ethanol) was added to a solution of Methyl 3-Bromo-2-(bromomethyl)benzoate in THF (30 mL). After stirring for 2 h the reaction mixture was concentrated to dryness and water (30 mL) was added with rapid stirring. The solids produced were isolated by filtration and dried to give the desired product
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d86e270ea2f442bba3cdda571d421e83 |
| Source note | uspto-grants-2015_08 |