Ethanol → 4-Bromo-2-methylisoindolin-1-one

HRID 511243ノート

反応式

HRID 511243 の反応式
[CH3:1][NH2:2].C(O)C.[Br:6][C:7]1[C:8]([CH2:17]Br)=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10](OC)=[O:11]>C1COCC1>[Br:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:9]2[C:8]=1[CH2:17][N:2]([CH3:1])[C:10]2=[O:11]

参加物

5

反応物 3

HCID 702EthanolHCID 6329MethylamineHCID 21907554Methyl 3-bromo-2-(bromomethyl)benzoate

生成物 1

HCID 219075344-Bromo-2-methylisoindolin-1-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methylamine in ethanol (10 mL, 80 mmol, 8M solution in ethanol) was added to a solution of Methyl 3-Bromo-2-(bromomethyl)benzoate in THF (30 mL). After stirring for 2 h the reaction mixture was concentrated to dryness and water (30 mL) was added with rapid stirring. The solids produced were isolated by filtration and dried to give the desired product

後処理

  1. concentrationwas concentrated to dryness and water (30 mL)
  2. additionwas added with rapid stirring
  3. customThe solids produced
  4. customwere isolated by filtration
  5. customdried

出典と根拠

ORDレコード
ord-d86e270ea2f442bba3cdda571d421e83
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

反応ノート

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