Hydrochloric Acid → HCID 49822344, compound

HRID 511251Notes

Reaction equation

HRID 511251 reaction equation
[CH3:1][N:2]([S:36]([CH3:39])(=[O:38])=[O:37])[C:3]1[C:8]([CH2:9][NH:10][C:11]2[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][N:14]=[C:13]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([P:28](=[O:35])([O:32]CC)[O:29]CC)=[CH:24][CH:23]=3)[N:12]=2)=[CH:7][CH:6]=[CH:5][N:4]=1.Cl>>[CH3:1][N:2]([S:36]([CH3:39])(=[O:38])=[O:37])[C:3]1[C:8]([CH2:9][NH:10][C:11]2[C:16]([C:17]([F:20])([F:18])[F:19])=[CH:15][N:14]=[C:13]([NH:21][C:22]3[CH:23]=[CH:24][C:25]([P:28](=[O:29])([OH:32])[OH:35])=[CH:26][CH:27]=3)[N:12]=2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 49822264HCID 49822264, compound

Product 1

HCID 49822344HCID 49822344, compound

Procedure

Also prepared by heating diethyl [4-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]phosphonate (Example 2) at 100° C. with an excess of concentrated hydrochloric acid for 6 h. The reaction mixture was concentrated in vacuo and the residue purified by preparative HPLC (MDP) afford the title compound.

Workup

  1. customAlso prepared
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue purified by preparative HPLC (MDP)

Sources & evidence

ORD record
ord-4cc1e43c3138409db04c26d6c808a9d7
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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