1-(Chloromethyl)-2-fluoro-5-methoxy-4-nitrobenzene → 5-(Chloromethyl)-1-fluoro-3-methoxy-2-nitrobenzene

HRID 511350Notes

Reaction equation

HRID 511350 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([N+:11]([O-:13])=[O:12])=[CH:5][C:4]=1F.[F:15]C1C=C(CO)C=C(OC)C=1[N+]([O-])=O>>[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([N+:11]([O-:13])=[O:12])=[C:5]([F:15])[CH:4]=1

Participants

3

Reactant 2

HCID 672551071-(Chloromethyl)-2-fluoro-5-methoxy-4-nitrobenzeneHCID 67256643(3-Fluoro-5-methoxy-4-nitrophenyl)methanol2×

Product 1

HCID 672544755-(Chloromethyl)-1-fluoro-3-methoxy-2-nitrobenzene

Procedure

The title compound was prepared using the procedure from Compound 130C (1-(chloromethyl)-2-fluoro-5-methoxy-4-nitrobenzene) with (3-fluoro-5-methoxy-4-nitrophenyl)methanol (Compound 146D). 1H NMR (CDCl3, 400 MHz): δ=3.96 (s, 3 H), 4.55 (s, 2 H), 6.87-6.90 (m, 2 H).

Sources & evidence

ORD record
ord-0e4044d231d1425090ccc8df184f2fea
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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